According to a study from Seoul, South Korea, "Surface modification of amine-terminated polyamidoamine (PAMAM) dendrimers by poly(ethylene glycol) (PEG) groups generally enhances water-solubility and biocompatibility for drug delivery applications. In order to provide guidelines for designing appropriate dendritic scaffolds, a series of G3 PAMAM-PEG dendrimer conjugates was synthesized by varying the number of PEG attachments and chain length (shorter PEG(550) and PEG(750) and longer PEG(2000))."
"Each conjugate was purified by size exclusion chromatography (SEC) and the molecular weight (MW) was determined by H-1 NMR integration and matrix-assisted laser desorption …
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